Humidity may not seem like an obvious cause of problems within cleanroom and pharmaceutical facilities. The truth is, poor humidity control is something that could result in production being non-compliant. Many materials and processes are greatly influenced by the relative humidity level, when areas go outside the specified parameters they often result in production processes being less efficient, less predictable, and more prone to producing products that don’t meet specification.
Formation of condensed moisture on the surfaces of production equipment (cooling tunnels) and at production facilities
Clumping and sticking together of hygroscopic products during pneumatic transportation
Adhesion of tablets to each other during coating (which increases volume of waste)
Changes in electrical conductivity
Product drying issues leading to low productivity
Loss of active components (drying at high temperatures)
Development of mildew and bacteria on products, at production and storage facilities
Adhesion of the packaging material to the product
Failures of electronic and electrical systems
Quicker deterioration of bearing constructions of buildings
Poor test equipment accuracy
Increased energy consumption
Reduced refrigeration plant efficiency
Ice build up on DX coils
High drying efficiency, low energy-consumption level
Efficient, consistent operation at low temperatures
Ease of installation
Compact size and low weight
Possibility to fully automate the process of humidity control
Corrosion-resistant construction (stainless steel, aluminium zinc)
Compliance with all acting directives and quality standards of the EU
Using desiccant dehumidification systems within production and storage facilities will ensure the recommended relative humidity and the necessary airflow conditions are maintained.
Increased production through accelerated product drying, can also be achieved throughout the production processes.
For example, by controlling the humidity level below 2.2 g/kg (below 20% RH at 18.0°Cdb) during production, coating of tablets or the drying of granulated products, the drying time can be reduced by up to 50%.
Within cleanroom facilities, humidity control is a critical yet often overlooked element of the clean room design process. Many processes, and materials are highly sensitive to fluctuations in relative humidity, that can lead to a range of problems. Ensuring both the correct temperature and humidity are maintained at all times throughout the year, is vital for continued validation of the facility and the processes being undertaken.